Ingredient Library, Undenatured Type II Collagen

Undenatured Type II Collagen (UC-II®) Reduces Exercise-Induced Inflammation and Cartilage Degradation in Healthy Labrador Retrievers

Studies have shown that undenatured type II collagen (UC-II®) can greatly decrease post-exercise inflammation and joint deterioration in healthy Labrador Retrievers. The level of inflammatory indicators and markers of cartilage impairment, including IL-6 and cartilage oligomeric matrix protein (COMP), decreased while joint cartilage integrity remained intact. Additional research has shown that UC-II® protects joint cartilage and prevents injury caused by movement while enhancing overall performance.

Read Article

Six-Month Supplementation with UC-II® Improves Pain, Lameness, and Joint Function in Dogs with Mild-to-Moderate Degenerative Joint Disease

Taking UC-II® regularly for six months can lead to improvements in pain, lameness, mobility, and joint function among dogs with mild to moderate degenerative joint disease. A study involving several clinical sites has revealed that UC-II® proves to be useful not only in terms of its safety profile but also in terms of its effectiveness when used as a long-term dietary supplement for dogs.

Read Article

UC-II® Alleviates Osteoarthritis in Rats by Suppressing NF-κB-Mediated Inflammation and Cartilage Degradation

Undenatured type II collagen (UC-II®) reduces the inflammation of joints and prevents the breakdown of cartilage in the joints of rats with osteoarthritis by reducing production of inflammation and metabolism products (IL-1β, IL-6, TNF-α, COX-2, MMP-3). The possible mechanisms causing this effect include blocking of the NF-κB pathway, reducing oxidative stress, and changing the processes that govern bone tissue metabolism (RANKL/OPG) providing important evidence for the efficacy of UC-II® in osteoarthritis treatment and joint health preservation.

Read Article

UC-II® Demonstrates Superior Joint Protection in Companion Animals with Osteoarthritis Compared to Conventional Supplements

The use of undenatured type II collagen (UC-II®) to treat pain, joint mobility, and function, with positive results in dogs and horses with osteoarthritis. UC-II® is able to act in a beneficial way at low doses. The results of several studies show that UC-II® is more effective than other medications such as glucosamine and chondroitin sulfate. The review indicates that UC-II® is a promising remedy that has been getting increasing recognition from scientific studies and can be used for nutritional treatment of osteoarthritis in pets.

Read Article